منابع مشابه
The Bio-assay of β-Estradiol *
Occasionally, a scientist makes a discovery which stands out clearly as the contribution which has had a profound effect on the subsequent developments and advance in a particular field of science. That Edgar Allen's introduction of the vaginal smear method' for detection of the "ovarian follicular hormone" was such a discovery is evidenced by the tremendous advances in our knowledge of ovarian...
متن کاملA Review on 17-β estradiol a Potent Therapeutic Factor of Diabetic Cardiomyopathy
Type 2 diabetes causes structural and functional changes in the myocardium, which is called cardiomyopathy. Diabetic cardiomyopathy (DCM) is a distinct primary disorder process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Also, DCM is a multifaceted disorder that is one of the leading causes of death in elderly and postmenopausal women. Menopause i...
متن کاملEstradiol Activates β-Catenin Dependent Transcription in Neurons
Estradiol may fulfill a plethora of functions in neurons, in which much of its activity is associated with its capacity to directly bind and dimerize estrogen receptors. This hormone-protein complex can either bind directly to estrogen response elements (ERE's) in gene promoters, or it may act as a cofactor at non-ERE sites interacting with other DNA-binding elements such as AP-1 or c-Jun. Many...
متن کاملEarly Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition
BACKGROUND It remains controversial whether hormone therapy in recently postmenopausal women modifies the risk of Alzheimer's disease (AD). OBJECTIVE To investigate the effects of hormone therapy on amyloid-β deposition in recently postmenopausal women. METHODS Participants within 5-36 months past menopause in the Kronos Early Estrogen Prevention Study, a randomized, double blinded placebo-...
متن کاملChronic estradiol - 17 β exposure increases superoxide production in the
1 Women are exposed to estrogen in several forms such as oral contraceptive pills and 2 hormone replacement therapy. Although estrogen was believed to be cardioprotective, 3 lately, its beneficial effects are being questioned. Recent studies indicate that oxidative 4 stress in the rostral ventrolateral medulla (RVLM) may play a role in the development of 5 hypertension. Therefore, we hypothesiz...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1937
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)74484-0